Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication and provide a rationale to redesign antiretroviral treatment for feline AIDS-2

Copyright information:Taken from "Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication and provide a rationale to redesign antiretroviral treatment for feline AIDS"http://www.retrovirology.com/content/4/1/79Retrovirology 2007;4():79-79.Published online 30 Oct 2007PMCID:PMC2244644.ologue [PDB:]. The level of similarity was calculated by the Swiss PDB Viewer (SPDBV) software. The color scale is that adopted by SPDBV. The transferred strand of proviral DNA is shown in magenta. Similarity is maximal at the level of the INSTI binding site. The INSTI binding site (indicated by a circle) is that calculated by some of us in previous works [16,20]. Panels B-C: Docking of CHI1019 (panel B) and L-870,810 (panel C) at the catalytic cavity of FIV IN. The protein is shown as Connolly surface (in green). Ligands are shown in CPK (carbon backbone in magenta). The terminal dinucleotide of 3' processed proviral DNA is shown in CPK (carbon backbone in orange). Metals are shown as spheres (in gray). Images prepared using Pymol (see Ref. [50]).