The number of cells expressing extranuclear high-mobility group chromosomal box protein 1 (HMGB1) is quantitatively comparable to the number of cells expressing tumor necrosis factor (TNF) and interleukin-1-beta (IL-1β) in arthritic joints

Copyright information:Taken from "Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis"http://arthritis-research.com/content/9/2/R35Arthritis Research & Therapy 2007;9(2):R35-R35.Published online 30 Mar 2007PMCID:PMC1906813. Representative micrographs illustrating immunohistochemical staining of synovial tissue from an arthritic animal at day 21 after immunization. Sequential cryocut sections were analyzed for expressions of HMGB1 , IL-1β , and TNF . Abundant expressions were demonstrated for all three cytokines. A section stained with an irrelevant isotype-matched control. Original magnification ×125.