In the ex vivo HOC-model the effect of a 21 days incubation with SRL (50 ng/ml) on reactive cell proliferation was studied in the neointima, plaque-intima, and media at day 21 and day 56

Copyright information:Taken from "Sirolimus inhibits key events of restenosis in vitro/ex vivo: evaluation of the clinical relevance of the data by SI/MPL- and SI/DES-ratio's"http://www.biomedcentral.com/1471-2261/7/15BMC Cardiovascular Disorders 2007;7():15-15.Published online 11 May 2007PMCID:PMC1878500. SRL inhibited reactive cell proliferation, statistical significance was achieved for the inhibitory effect on cell proliferation in the media at day 21 (SI/MPL-ratio: 7.81).