Antitumor activities of cyclopamine and γ-secretase inhibitor against HEKTER-LUK and HEKTER-ST cell lines

Copyright information:Taken from "Cross-platform expression profiling demonstrates that SV40 small tumor antigen activates Notch, Hedgehog, and Wnt signaling in human cells"BMC Cancer 2006;6():54-54.Published online 7 Mar 2006PMCID:PMC1420312.Copyright © 2006 Ali-Seyed et al; licensee BioMed Central Ltd. Survival of HEK-TERV and HEK-TERST cells determined by MTT assay after treatment with vehicle, 2.4μM Cyclopamine or 1 nM γ-secretase inhibitor for 72 hrs. Mean and standard error are shown for each treatment. Percent cell survival was computed relative to untreated cells. Survival of HEK-TERST cells determined by Trypan Blue exclusion assay after treatment of 1 × 10cells with vehicle, 2.4μM Cyclopamine or 1 nM γ-secretase inhibitor for 72 hrs.