Histopathology (haematoxylin and eosin) and immunohistochemistry (double staining: indirect immunoperoxidase and alcaline phosphatase in insert of parts a and b) of rheumatoid synovial tissue from three different anatomical locations of the RA patient

Copyright information:Taken from "IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process"Arthritis Research 2000;2(4):303-314.Published online 19 May 2000PMCID:PMC17813.Copyright © 2000 Current Science Ltd These are as follows: right peroneal tendon sheath; left peroneal tendon sheath with inserted figure showing Ki-M4 positive FDC network (brown) surrounded by CD20 B lymphocytes (blue), representing a germinal center; and synovial membrane from the right cubita. Arrows indicate enlarged synovial intima (original magnification 350×).