ETS exposure has no overall effect in 6-week-old Balb/c mice () and increases AHR in 10-week-old mice ()

Copyright information:Taken from " Exposure to Environmental Tobacco Smoke Potentiates Adult Responses to Allergen in BALB/c Mice"Environmental Health Perspectives 2007;115(4):548-555.Published online 4 Jan 2007PMCID:PMC1852677.This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI Mice received graded doses (1.56–50 mg/mL) of nebulized methacholine, and AHR, expressed as Penh values, was determined by noninvasive, whole-body plethysmography. In () at the two highest doses, AHR is increased in ETS mice [the asterisk (*) indicates significant difference ( ≤ 0.017)]; these points were not sufficient to create a significant difference in overall response curves. In (), ETS exposure increased AHR in 10-week-old mice [the asterisk (*) indicates significant difference between all groups; ** indicates significant difference between AS and both AO and ES ( < 0.0001)]. Bars represent mean ± SE.