Prolonged oscillations in the nuclear levels of fluorescently tagged p53 and Mdm2 in individual MCF7, U280, cells following gamma irradiation

Copyright information:Taken from "Oscillations and variability in the p53 system"Molecular Systems Biology 2006;2():2006.0033-2006.0033.Published online 13 Jun 2006PMCID:PMC1681500.Copyright © 2006, EMBO and Nature Publishing Group () Time-lapse fluorescence images of one cell over 29 h after 5 Gy of gamma irradiation. Nuclear p53-CFP and Mdm2-YFP are imaged in green and red, respectively. Time is indicated in hours. () Normalized nuclear fluorescence levels of p53-CFP (green) and Mdm2-YFP (red) following gamma irradiation. Top left: the cell shown in panel A. Other panels: five cells from one field of view, after exposure to 2.5 Gy gamma irradiation.