Signature gene clusters at different phases of autoimmune arthritis

Copyright information:Taken from "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation"Arthritis Research & Therapy 2004;7(2):R196-R207.Published online 14 Dec 2004PMCID:PMC1065315.Copyright © 2004 Adarichev et al.; licensee BioMed Central Ltd. Hierarchical clustering was performed for genes whose expression significantly differed when paws of naive mice (AN) were compared with those in the pre-arthritic (PA), acute (AA), or chronic (CA) phases of arthritis. The total number of genes (= 507) is less than the sum of the phase-specific genes because of partial overlap (Fig. 2). Rows represent individual genes; columns represent individual expression values for each gene at the indicated phase of arthritis. The major biological activities, specific for each cluster, were examined by using functional clustering of genes. This analysis yielded four different expression patterns (clusters I–IV). Upregulated genes are shown in red, downregulated genes in blue.