Fluorescence associated cell sorting analysis of MCF 7 cells treated with andrographolide (5 μM) or DRF 3188 (5 μM) for a period of 24 hours

Copyright information:Taken from "DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells"BMC Cancer 2004;4():26-26.Published online 18 Jun 2004PMCID:PMC441383.Copyright © 2004 Satyanarayana et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Lovastatin (10 μM) and Butyrolactone (10 μM) were used as positive controls. Andrographolide and DRF 3188 exhibit a G0-G1 arrest like Lovastatin. Butyrolactone treated MCF 7 cells exhibit a G2-M arrest. After a 48 h treatment with Andrographolide or DRF 3188 MCF7 cells exhibit a G0-G1 arrest, similar to Lovastatin. Butyrolactone treated cells exhibit a G2-M arrest.