Dopamine presynaptically and heterogeneously modulates nucleus accumbens medium-spiny neuron GABA synapses -2

Copyright information:Taken from "Dopamine presynaptically and heterogeneously modulates nucleus accumbens medium-spiny neuron GABA synapses "BMC Neuroscience 2006;7():53-53.Published online 30 Jun 2006PMCID:PMC1538613.A1) DA () inhibited the autaptic response, here to 52% of control. (A2) Application of the D1 antagonist SCH23390 (SCH) together with Sulpiride (Sulp) had no impact on the response (), but blocked DA action (). (A3) In this experiment, the DA inhibition was D2-mediated, as Sulpiride blocked DA action completely (), while SCH23390 had only a modest effect. (A4) At the end of the experiment, gabazine (gray trace) completely blocked the autaptic response. . In another cell, (B1) the autaptic connection did not show DA modulation. However, (B2) Norepinephrine (NE; 68% inhibition) and (B3) Serotonin (5-HT; 78% inhibition) inhibited the autaptic response, arguing that DA does not act through other monoamine receptors. (B4) At the end of the experiment, the autaptic response was completely blocked by Gabazine.