Divergent transforming growth factor (TGF)-β gene activation and biological responses in MCF-7 and MDA-MB-231 cell lines

Copyright information:Taken from "HER-2 overexpression differentially alters transforming growth factor-β responses in luminal versus mesenchymal human breast cancer cells"Breast Cancer Research 2005;7(6):R1058-R1079.Published online 8 Nov 2005PMCID:PMC1410754.Copyright © 2005 Wilson et al.; licensee BioMed Central Ltd. The TGF-β induced transcriptional program is almost entirely non-overlapping in the luminal MCF-7 and the mesenchymal MDA-MB-231 breast cancer cell lines. The number of genes induced and repressed greater than 1.5-fold with a p-value < 0.01 after a 24 h exposure to TGF-β are shown. All of the individual genes commonly affected in both control cell lines (MCF-7 CN and MDA-MB-231 CN) are listed below the diagram. Model for the differential outcomes of TGF-β stimulation in estrogen receptor (ER) positive luminal breast cells compared to ER-negative mesenchymal cells. Model for context specific effects of HER-2 overexpression on TGF-β signaling in ER-positive luminal cells versus ER-negative mesenchymal cells. EMT, epithelial to mesenchymal transition.