An hA3A mutant bearing a defective cytidine deaminase active site remains able to inhibit IAP retrotransposition

Copyright information:Taken from "APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells"Nucleic Acids Research 2006;34(1):89-95.Published online 10 Jan 2006PMCID:PMC1326241.© The Author 2006. Published by Oxford University Press. All rights reserved These data were derived and are presented as described in and again used a primary antibody specific for the HA epitope tag, present on both the β-arrestin and hA3A proteins, in the lower panel. The hA3A (SPC-AAA) mutant bears alanine residues in place of the active site residues 99-SPC-101.