Sequence and structure of the cDNA encoding fibrillarin (NCBI accession no

Copyright information:Taken from "Unusual features of fibrillarin cDNA and gene structure in : evolutionary conservation of core proteins and structural predictions for methylation-guide box C/D snoRNPs throughout the domain Eucarya"Nucleic Acids Research 2005;33(9):2781-2791.Published online 13 May 2005PMCID:PMC1126904.© The Author 2005. Published by Oxford University Press. All rights reserved AF110181). Predicted positions of transcription initiation are indicated with arrows. The position of the translation stop codon is bolded and underlined. Additional detected sites of mRNA polyadenylation are shown as filled diamonds. One-letter amino acid abbreviations for the sequence at the amino terminal end of the protein are shown and the GK-rich region is highlighted in gray. The conserved PH dipeptide sequence discussed in the text is bolded. At the bottom of the sequence is a schematic diagram of the fibrillarin protein domain structure. The highly conserved methyltransferase domain, located between amino acid positions 102 and 252, is depicted by the hatched box and the GK repeat by the striped box.