Responses to MMS

Copyright information:Taken from "APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability"Nucleic Acids Research 2005;33(1):298-306.Published online 12 Jan 2005PMCID:PMC546158.© 2005, the authors © () Levels of SSBs and AP sites induced by treating various CHO cell lines with 100 μM MMS for 30 min at 37°C as determined by alkaline elution at the end of the treatment (0 min) or after 15 min of recovery. ( and ) Effect of APE1 overproduction on survival to MMS treatment. Cells were treated with MMS for 1 h at 37°C at the indicated doses. Surviving clones (>50 cells) were scored after 8 days. Values represent the mean of at least three independent experiments ± SD.