Effect of subtype-specific opoid peptides on KCl-stimulted HGABA release

Copyright information:Taken from "Opioid modulation of GABA release in the rat inferior colliculus"BMC Neuroscience 2004;5():31-31.Published online 7 Sep 2004PMCID:PMC517931.Copyright © 2004 Tongjaroenbungam et al; licensee BioMed Central Ltd. DAMGO, DADLE and U69593 (1 μM) were perfused as described for morphine in Figure 1. Data represent averages ± SEM. Labels on the x-axis indicate concentration of drugs present during S2. Only the μ-opioid receptor specific neuropeptide DAMGO produced a statistically significant effect (p < 0.01, One way ANOVA) on KCl-stimulted [H]GABA release as compared to the controls (a) where no opiate drug was used. The effect of DAMGO was antagonised by 10 μM naloxone which was perfused from one fraction before the perfusion of DAMGO (b).