The distribution of telomeres in the nucleus of three typical cells selected from the G0/G1 phase (upper row), S phase (middle row) and G2/M phase (lower row)

Copyright information:Taken from "The three-dimensional organization of telomeres in the nucleus of mammalian cells"BMC Biology 2004;2():12-12.Published online 3 Jun 2004PMCID:PMC425602.Copyright © 2004 Chuang et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Each telomere distribution is shown from a top view (the plane), along the optical axis (left column), from a side view (plane) as observed along the axis (centre column) and as a 3D image of the telomeres in an open nucleus (right column). When shown from the top and side views, the telomeres are displayed on top of the projected image of the nucleus. This projection demonstrates the extent of the chromatin (and therefore chromosomes) and defines the volume and borderline of the nucleus.