Assessment of the four methods by recovery of links between members of known protein complexes

Copyright information:Taken from "Prolinks: a database of protein functional linkages derived from coevolution"Genome Biology 2004;5(5):R35-R35.Published online 16 Apr 2004PMCID:PMC416471.Copyright © 2004 Bowers et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. We test to see how often predicted interacting protein pairs are subunits of the same protein complex. protein complexes were obtained from the EcoCyc database. Again, the ROC curve shows the performance of the rank-ordered list of all predicted interactions (solid line) compared with the random selection of protein pairs (dashed line), in their ability to recover constituents of known protein complexes.