Animals were maintained melatonin-free under simulated natural photoperiodic conditions in a light-proof building for 2 years

Copyright information:Taken from "Changes in the 5-HT2receptor system in the pre-mammillary hypothalamus of the ewe are related to regulation of LH pulsatile secretion by an endogenous circannual rhythm"BMC Neuroscience 2003;4():1-1.Published online 28 Jan 2003http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149365/Copyright © 2003 Chemineau et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. The upper graph depicts LH profiles in one ewe in the High stage of the endogenous rhythm at the end of the experiment and the lower graph LH profile of one ewe in the Low stage. Inserts depict LH pulsatile secretory profiles at the end of the experiment (blood sampled every 6 min for 4 hours).