Histogram depicting the distribution of B-cell frequencies in the peripheral circulation from 94 rheumatoid arthritis (RA) patients

Copyright information:Taken from "B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response"Arthritis Research 2002;4(4):R1-R1.Published online 2 May 2002PMCID:PMC125293.Copyright © 2002 Wagner et al., licensee BioMed Central Ltd The percentage of CD19 cells from total peripheral lymphocytes is plotted on the axis, and the number of patients in each frequency range is plotted on the axis. The overlays represent the Gaussian frequency distributions fitted to the two populations. Percentage of CD19 B cells in the peripheral circulation in patients negative (SE-) and positive (SE+) for the RA-associated shared epitope and in age-matched healthy controls. Bars depicts mean and standard error of the mean. = 0.05 compared with healthy controls, = 0.02 compared with healthy controls, < 0.001 compared with SE-positive RA patients.