Additional file 4 of Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment

Supplementary Material 4. Figure S4: DNA repair inhibitor responses in all tested PDX tumor models. (A) Tumor growth velocities and normalized tumor volume are shown for each PDX model treated with Olaparib. (B) Dose-escalation and (C) combination therapy with other agents were performed in select PDX models. (D) Growth velocity and normalized tumor volume are shown with NU7441 treatment. All tested PDX models are listed for each drug. P-values are calculated with the student T-test per Hather 2014 [ 49 ].