The activation was evaluated by the immunoreactivity for pERK

(a) Representative pictures of pERK signals in the ipsilateral spinal dorsal horn after electrical stimulation to the right hind paw (see Methods). The figures in the bottom of each picture indicate pERK signals, which were used for pERK quantification (see Methods). Representative pictures of spinal antagonism of the pERK signals induced by 250 or 5 Hz stimuli (b), and the results of pERK quantification (c).: vehicle (Veh; aCSF), CP-99994 (CP) (10 nmol), MK-801 (MK) (30 nmol), AP-5 (30 nmol), CNQX (10 nmol). *: < 0.05 no stimulus, #: < 0.05 vehicle. Data represent the means ± S.E.M. from experiments using at least 4 mice. Scale bar = 100 μm.Copyright information:Taken from "Pharmacological switch in Aβ-fiber stimulation-induced spinal transmission in mice with partial sciatic nerve injury"http://www.molecularpain.com/content/4/1/25Molecular Pain 2008;4():25-25.Published online 11 Jul 2008PMCID:PMC2488330.