Additional file 5 of TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy
Additional file 5: Figure S5. Semi-quantification of oil-red staining. A. FIG3.G: lipid droplet accumulation in ccRCC cells was significantly decreased by TBC1D5 overexpression. B. FIG4.G: chloroquine promote lipid accumulation in ccRCC, rapamycin inhibit lipid accumulation in ccRCC, chloroquine rev...
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| creator | Huang, Yu Xiong, Zhiyong Wang, Jianjun Gao, Yafen Cao, Qi Wang, Decai Shi, Jian Chen, Zhixian Yang, Xiong |
| description | Additional file 5: Figure S5. Semi-quantification of oil-red staining. A. FIG3.G: lipid droplet accumulation in ccRCC cells was significantly decreased by TBC1D5 overexpression. B. FIG4.G: chloroquine promote lipid accumulation in ccRCC, rapamycin inhibit lipid accumulation in ccRCC, chloroquine reverse the inhibitory effect by TBC1D5 overexpression, while rapamycin is in synergy with TBC1D5 overexpression. C. FIG5.E: lipid accumulation in cells significantly reduced after HIF-2α knockdown, knockdown of TBC1D5 significantly increased lipid accumulation, knockdown of both HIF-2α and TBC1D5 can reverse the decreased lipid accumulation caused by knockdown of HIF-2α alone. *P |
| doi_str_mv | 10.6084/m9.figshare.26686527 |
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Semi-quantification of oil-red staining. A. FIG3.G: lipid droplet accumulation in ccRCC cells was significantly decreased by TBC1D5 overexpression. B. FIG4.G: chloroquine promote lipid accumulation in ccRCC, rapamycin inhibit lipid accumulation in ccRCC, chloroquine reverse the inhibitory effect by TBC1D5 overexpression, while rapamycin is in synergy with TBC1D5 overexpression. C. FIG5.E: lipid accumulation in cells significantly reduced after HIF-2α knockdown, knockdown of TBC1D5 significantly increased lipid accumulation, knockdown of both HIF-2α and TBC1D5 can reverse the decreased lipid accumulation caused by knockdown of HIF-2α alone. *P < 0.05, **P < 0.01, ***P < 0.001.</description><identifier>DOI: 10.6084/m9.figshare.26686527</identifier><language>eng</language><publisher>figshare</publisher><subject>Biochemistry ; Biological Sciences not elsewhere classified ; Biophysics ; Cancer ; Cell Biology ; Computational Biology ; FOS: Biological sciences ; Genetics ; Medicine ; Molecular Biology ; Pharmacology ; Physiology</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1816-4818</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780,1894</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.6084/m9.figshare.26686527$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Huang, Yu</creatorcontrib><creatorcontrib>Xiong, Zhiyong</creatorcontrib><creatorcontrib>Wang, Jianjun</creatorcontrib><creatorcontrib>Gao, Yafen</creatorcontrib><creatorcontrib>Cao, Qi</creatorcontrib><creatorcontrib>Wang, Decai</creatorcontrib><creatorcontrib>Shi, Jian</creatorcontrib><creatorcontrib>Chen, Zhixian</creatorcontrib><creatorcontrib>Yang, Xiong</creatorcontrib><title>Additional file 5 of TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy</title><description>Additional file 5: Figure S5. Semi-quantification of oil-red staining. A. FIG3.G: lipid droplet accumulation in ccRCC cells was significantly decreased by TBC1D5 overexpression. B. FIG4.G: chloroquine promote lipid accumulation in ccRCC, rapamycin inhibit lipid accumulation in ccRCC, chloroquine reverse the inhibitory effect by TBC1D5 overexpression, while rapamycin is in synergy with TBC1D5 overexpression. C. FIG5.E: lipid accumulation in cells significantly reduced after HIF-2α knockdown, knockdown of TBC1D5 significantly increased lipid accumulation, knockdown of both HIF-2α and TBC1D5 can reverse the decreased lipid accumulation caused by knockdown of HIF-2α alone. *P < 0.05, **P < 0.01, ***P < 0.001.</description><subject>Biochemistry</subject><subject>Biological Sciences not elsewhere classified</subject><subject>Biophysics</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Computational Biology</subject><subject>FOS: Biological sciences</subject><subject>Genetics</subject><subject>Medicine</subject><subject>Molecular Biology</subject><subject>Pharmacology</subject><subject>Physiology</subject><fulltext>true</fulltext><rsrctype>image</rsrctype><creationdate>2024</creationdate><recordtype>image</recordtype><sourceid>PQ8</sourceid><recordid>eNqdjz1Ow0AQhd1QIOAGFHOBOLaJnaQkgSj06Vfj9Xg90v5pd43kE1FzEc6EHZELUL3R05v39GXZc1nkTbHbrM0-71nFAQPlVdPsmrra3mdfr13HiZ1FDT1rghpcD5fDsXyrIdAnhUgR0kAg0WPLmtO0JM4fp1X18w1sIY3GBfDBqUAxzlWAtgPNnjswlLB1mqNZklITBpCk9Vy9LF5PiUGydQahnWZfjRoTW3UdxTE5P6CaHrO7HnWkpz99yDan98vxvOowoeREwgc2GCZRFmLhFWYvbrzixvvyz7dfBB1sCQ</recordid><startdate>20240814</startdate><enddate>20240814</enddate><creator>Huang, Yu</creator><creator>Xiong, Zhiyong</creator><creator>Wang, Jianjun</creator><creator>Gao, Yafen</creator><creator>Cao, Qi</creator><creator>Wang, Decai</creator><creator>Shi, Jian</creator><creator>Chen, Zhixian</creator><creator>Yang, Xiong</creator><general>figshare</general><scope>DYCCY</scope><scope>PQ8</scope><orcidid>https://orcid.org/0000-0002-1816-4818</orcidid></search><sort><creationdate>20240814</creationdate><title>Additional file 5 of TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy</title><author>Huang, Yu ; Xiong, Zhiyong ; Wang, Jianjun ; Gao, Yafen ; Cao, Qi ; Wang, Decai ; Shi, Jian ; Chen, Zhixian ; Yang, Xiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-datacite_primary_10_6084_m9_figshare_266865273</frbrgroupid><rsrctype>images</rsrctype><prefilter>images</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biochemistry</topic><topic>Biological Sciences not elsewhere classified</topic><topic>Biophysics</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Computational Biology</topic><topic>FOS: Biological sciences</topic><topic>Genetics</topic><topic>Medicine</topic><topic>Molecular Biology</topic><topic>Pharmacology</topic><topic>Physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Huang, Yu</creatorcontrib><creatorcontrib>Xiong, Zhiyong</creatorcontrib><creatorcontrib>Wang, Jianjun</creatorcontrib><creatorcontrib>Gao, Yafen</creatorcontrib><creatorcontrib>Cao, Qi</creatorcontrib><creatorcontrib>Wang, Decai</creatorcontrib><creatorcontrib>Shi, Jian</creatorcontrib><creatorcontrib>Chen, Zhixian</creatorcontrib><creatorcontrib>Yang, Xiong</creatorcontrib><collection>DataCite (Open Access)</collection><collection>DataCite</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Huang, Yu</au><au>Xiong, Zhiyong</au><au>Wang, Jianjun</au><au>Gao, Yafen</au><au>Cao, Qi</au><au>Wang, Decai</au><au>Shi, Jian</au><au>Chen, Zhixian</au><au>Yang, Xiong</au><format>book</format><genre>unknown</genre><ristype>GEN</ristype><title>Additional file 5 of TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy</title><date>2024-08-14</date><risdate>2024</risdate><abstract>Additional file 5: Figure S5. Semi-quantification of oil-red staining. A. FIG3.G: lipid droplet accumulation in ccRCC cells was significantly decreased by TBC1D5 overexpression. B. FIG4.G: chloroquine promote lipid accumulation in ccRCC, rapamycin inhibit lipid accumulation in ccRCC, chloroquine reverse the inhibitory effect by TBC1D5 overexpression, while rapamycin is in synergy with TBC1D5 overexpression. C. FIG5.E: lipid accumulation in cells significantly reduced after HIF-2α knockdown, knockdown of TBC1D5 significantly increased lipid accumulation, knockdown of both HIF-2α and TBC1D5 can reverse the decreased lipid accumulation caused by knockdown of HIF-2α alone. *P < 0.05, **P < 0.01, ***P < 0.001.</abstract><pub>figshare</pub><doi>10.6084/m9.figshare.26686527</doi><orcidid>https://orcid.org/0000-0002-1816-4818</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Additional file 5 of TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy |
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