Additional file 12 of Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB — GRB2/ERK/RUNX2 pathway

Additional file 12 of Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB — GRB2/ERK/RUNX2 pathway

Additional file 12: Figure S2. PDGFB pathway regulation in ADSCs. A, The mRNA expression of GRB2 and RUNX2 with/without the treatments of PDGFB and ERK inhibitor. B, The mRNA expression of several key genes in GRB2-pERK-RUNX2 axis and osteogenesis-related genes, in dose-dependent groups. C-D, Wester...

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Hauptverfasser: Tang, Yulong, Yang, Kai, Liu, Qingmei, Ma, Yanyun, Zhu, Hao, Tang, Kunhai, Geng, Chengchun, Xie, Jiangnan, Zhuo, Dachun, Wu, Wenyu, Jin, Li, Xiao, Wenze, Wang, Jiucun, Zhu, Qi, Liu, Jing
Format: Bild
Sprache:eng
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Biochemistry
Biological Sciences not elsewhere classified
Cancer
Developmental Biology
FOS: Biological sciences
FOS: Clinical medicine
FOS: Health sciences
Genetics
Immunology
Infectious Diseases
Medicine
Molecular Biology
Physiology
Space Science
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Zusammenfassung:Additional file 12: Figure S2. PDGFB pathway regulation in ADSCs. A, The mRNA expression of GRB2 and RUNX2 with/without the treatments of PDGFB and ERK inhibitor. B, The mRNA expression of several key genes in GRB2-pERK-RUNX2 axis and osteogenesis-related genes, in dose-dependent groups. C-D, Western blot of several key molecules in the axis with the treatment of PDGFB in time-dependent groups. E, The mRNA expression of several key genes in the axis and osteogenesis-related genes, in time-dependent groups.
DOI:10.6084/m9.figshare.26623165