A mathematical model of glutathione metabolism-1

A mathematical model of glutathione metabolism-1

Ionine, glycine, glutamate, and serine are reduced to 1/3 of normal. The intracellular GSH + GSSG concentration declines slowly over the 48 hour period to about 50% of normal and the rate of GSH export declines to 67% of normal consistent with the experiments reported in [33]. The cytosolic and bloo...

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Hauptverfasser: Reed, Michael C, Thomas, Rachel L, Pavisic, Jovana, S Jill James, Ulrich, Cornelia M, H Frederik Nijhout
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Sprache:eng
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Zusammenfassung:Ionine, glycine, glutamate, and serine are reduced to 1/3 of normal. The intracellular GSH + GSSG concentration declines slowly over the 48 hour period to about 50% of normal and the rate of GSH export declines to 67% of normal consistent with the experiments reported in [33]. The cytosolic and blood cysteine concentrations decline proportionally to GSH. The methionine cycle metabolites and fluxes equilibrate rapidly.Copyright information:Taken from "A mathematical model of glutathione metabolism"http://www.tbiomed.com/content/5/1/8Theoretical Biology & Medical Modelling 2008;5():8-8.Published online 28 Apr 2008PMCID:PMC2391141.
DOI:10.6084/m9.figshare.25863