(A) Wild type

PKP2 recruits PKC to DP cytoplasmic complexes, where phosphorylation of DP at Ser2849 modulates its interaction with IF and allows DP assembly into cell–cell junctions. (B) PKP2 deficiency. PKC is no longer recruited to DP complexes and is free to phosphorylate other substrates, leading to aberrant...

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Bibliographische Detailangaben
Hauptverfasser:	E. Bass-Zubek, Amanda, P. Hobbs, Ryan, V. Amargo, Evangeline, J. Garcia, Nicholas, N. Hsieh, Sherry, Chen, Xinyu, K. Wahl, James, F. Denning, Mitchell, J. Green, Kathleen
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Sprache:	eng
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Beschreibung
Zusammenfassung:	PKP2 recruits PKC to DP cytoplasmic complexes, where phosphorylation of DP at Ser2849 modulates its interaction with IF and allows DP assembly into cell–cell junctions. (B) PKP2 deficiency. PKC is no longer recruited to DP complexes and is free to phosphorylate other substrates, leading to aberrant accumulation of DP along IF and impaired DP assembly.Copyright information:Taken from "Plakophilin 2: a critical scaffold for PKCα that regulates intercellular junction assembly"The Journal of Cell Biology 2008;181(4):605-613.Published online 19 May 2008PMCID:PMC2386101.
DOI:	10.6084/m9.figshare.25709