A Secure Data Lake for the CFDE Community on CAVATICA – Powered by Interoperability Standards

The ability to provide actionable data to researchers is one of the main goals of the Velsera’s platforms. Here we showcase the integration of data from 10+ datasets coming from different consortia and repositories in the CAVATICA Platform using the DRS standard and the GA4GH Passport. The DRS standards provide the ability to integrate several DRS servers, even though these servers are provisioned by different teams in different organizations. At the same time, the GA4GH Passport provides the ability to handle the controlled data with the right authorization level simultaneously with open access data. We demonstrate how a user can access data from TCGA, TARGET, TCIA, CPTAC, Kids First, INCLUDE, AnVIL, CBTTC, OpenPTBA, TOPMED and UDN all from the same project. The collected data can be accessed by the user with the proper authorization on the CAVATICA platform following which they can be used transparently in tasks. Tasks are workflow executions launched from the CAVATICA Platform in a CAVATICA Project, or in Data Studio environment. All analyses can be shared with other users on CAVATICA with appropriate permission controls.