Relationship of chromosomes OAR11 and BTA19 to HSA17

The segments of HSA17 corresponding to groups of BAC-CGCs predicted to be syntenic are shown by blue vertical lines with an arrowhead at one end, in the order in which they occur in the human genome. The arrowheads in the map of OAR11 show the order and the orientation of the syntenic segments in the sheep genome with respect to the human genome: blue, same orientation; and red, reversed orientation (with Mb scale on the left). The solid lines link syntenic segments with the same orientation in the sheep and human genomes and the dotted lines link syntenic segments inverted in the sheep genome relative to the human genome. The larger black dot indicates the location of the human centromere and the predicted location in the other genomes. The numbers to the left of the syntenic segments indicate the IDs of the cMegaBAC-CGCs built on the human genome. On the far right is shown an equivalent representation of BTA19 built using BAC fingerprinting and limited BAC end sequencing data, adapted from Everts-van der Wind and coworkers [11]. Two small inversions in the cow assembly identified from the BAC end sequencing are indicated by 'x'. BAC, bacterial artificial chromosome; BTA, cow chromosome; CGC, comparative genome contig; HSA, human chromosome; Mb, megabase; OAR, sheep chromosome.Copyright information:Taken from "Using comparative genomics to reorder the human genome sequence into a virtual sheep genome"http://genomebiology.com/2007/8/7/R152Genome Biology 2007;8(7):R152-R152.Published online 30 Jul 2007PMCID:PMC2323240.