Comparison of the interaction map with other datasets

The interactions found in common, or overlap (red dots) between the two-hybrid map and interologs predicted from other organisms, were determined. This was compared to the overlap between the interolog datasets and 2,000 random maps generated by randomly switching pairs of links in the original yeast two-hybrid map, which preserves network degree distribution. The two-hybrid map shared 28 interactions with a reference set containing 147 interologs of low-throughput literature-cited protein interactions, significantly greater than the overlap with the random maps. There were 50 interactions shared with 1,165 interologs predicted from the protein interaction dataset [11]. There were 124 interactions shared with a set of 3,743 interologs predicted from a large-scale protein complex study [1]. There were 76 interactions shared with a set of 4,056 interologs predicted from a second protein complex pull-down study [6]. A complete list of the predicted interologs used for these analyses can be found in Additional data file 12.Copyright information:Taken from "A proteome-wide protein interaction map for "http://genomebiology.com/2007/8/7/R130Genome Biology 2007;8(7):R130-R130.Published online 5 Jul 2007PMCID:PMC2323224.