Imp-L2 controls body and organ size

Tangential section through an adult eye containing an overexpression clone marked by the lack of red pigment. Within the clone, the size of the ommatidia is reduced. Wild-type ommatidia close to the clone are also smaller (compare black circled areas). Eye-specific overexpression of UASreduces male body weight (-38.3%, = 7 × 10). Overexpression of UASby ppl-results in a 56.1% weight reduction in male flies, whereas ppl-driven expression of UASresults in lethality (†). = 3 × 10. Loss of function increases body size in males (top) and females (bottom). Analyses of male and female weights. Wing area, cell number and cell size were assessed in female adult wings. GR indicates genomic rescue construct. -values are indicated by numbers as follows: 1, 2 × 10; 2, 8 × 10; 3, 9 × 10; 4, 6 × 10; 5, 3 × 10; 6, 1 × 10; 7, 8 × 10; 8, 2 × 10; 9, 4 × 10; 10, 4 × 10; 11, 3 × 10; 12, 1 × 10. Genotypes: 'control' , /; 'Imp-L2' ; /; 'Imp-L2' for the weight analysis (e) ; /+; 'Imp-L2' for the wing analysis (e) ; /+; 'Imp-L2, GR' ; /, ; 'Imp-L2, GR' ; , /+. -values were determined using unpaired Student's -test against the control except in (4) where the weight of IMP-L2 was compared to IMP-L2. n = 40 for the weight analysis in (b,c,e); n = 12 for the wing analysis in (e). Error bars represent s.d.Copyright information:Taken from "Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in and is essential for starvation resistance"http://jbiol.com/content/7/3/10Journal of Biology 2008;7(3):10-10.Published online 15 Apr 2008PMCID:PMC2323038.