Enzymatic b-elimination in natural product O- and C-glycoside deglycosylation

Enzymatic b-elimination in natural product O- and C-glycoside deglycosylation

Here, the authors show convergent evolution of -eliminase active sites for the cleavage of natural product 3-keto-O-glycosides. C-Glycoside cleavage is a specialized feature of this active site elicited by finely tuned enzyme-aglycone interactions.

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Hauptverfasser: Bitter, Johannes, Pfeiffer, Martin, Borg, Annika J. E., Kuhlmann, Kirill, Pavkov-Keller, Tea, Sánchez-Murcia, Pedro Alejandro, Nidetzky, Bernd
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Biocatalysis and Enzyme Technology
Biochemistry
Medical Biochemistry: Carbohydrates
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creator Bitter, Johannes
Pfeiffer, Martin
Borg, Annika J. E.
Kuhlmann, Kirill
Pavkov-Keller, Tea
Sánchez-Murcia, Pedro Alejandro
Nidetzky, Bernd
description Here, the authors show convergent evolution of -eliminase active sites for the cleavage of natural product 3-keto-O-glycosides. C-Glycoside cleavage is a specialized feature of this active site elicited by finely tuned enzyme-aglycone interactions.
doi_str_mv 10.6084/m9.figshare.24260761
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identifier DOI: 10.6084/m9.figshare.24260761
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subjects Biocatalysis and Enzyme Technology
Biochemistry
Medical Biochemistry: Carbohydrates
title Enzymatic b-elimination in natural product O- and C-glycoside deglycosylation
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