Enzymatic b-elimination in natural product O- and C-glycoside deglycosylation

Enzymatic b-elimination in natural product O- and C-glycoside deglycosylation

Here, the authors show convergent evolution of -eliminase active sites for the cleavage of natural product 3-keto-O-glycosides. C-Glycoside cleavage is a specialized feature of this active site elicited by finely tuned enzyme-aglycone interactions.

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Bibliographische Detailangaben
Hauptverfasser: Bitter, Johannes, Pfeiffer, Martin, Borg, Annika J. E., Kuhlmann, Kirill, Pavkov-Keller, Tea, Sánchez-Murcia, Pedro Alejandro, Nidetzky, Bernd
Format: Dataset
Sprache:eng
Schlagworte:
Biocatalysis and Enzyme Technology
Biochemistry
Medical Biochemistry: Carbohydrates
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Beschreibung
Zusammenfassung:Here, the authors show convergent evolution of -eliminase active sites for the cleavage of natural product 3-keto-O-glycosides. C-Glycoside cleavage is a specialized feature of this active site elicited by finely tuned enzyme-aglycone interactions.
DOI:10.6084/m9.figshare.24260761