Supplementary Material for: Relationships among non-neoplastic histopathological features, kidney function, proteinuria, and other clinical factors in patients undergoing nephrectomy

Introduction. The non-neoplastic kidney parenchyma from nephrectomies is often overlooked in routine examination. We aimed to evaluate the associations between global glomerulosclerosis (GS), interstitial fibrosis (IF) or arteriosclerosis (AS), with estimated glomerular filtration rate (eGFR), dipstick proteinuria, and other clinical factors. Methods. We performed a cross-sectional analysis of 781 patients with nephrectomy. We used regression models with and without interaction factors. The tested exposures were GS, IF or AS and the outcome measures were GFR and dipstick proteinuria. Results In multivariable analyses, increasing degrees of GS, IF, or AS were significantly associated with lower eGFR and proteinuria (p50% was associated with lower eGFR in patients with (-11 ml/min/1.73m2) than without (-6 ml/min/1.73m2) proteinuria; and AS >50% was associated with lower eGFR in patients with (-23 ml/min/1.73m2) than without (-7 ml/min/1.73m2) CVD. Conclusion. Greater degrees of each GS, IF, and AS are independently associated with proteinuria and lower eGFR. Obesity, HTN, proteinuria, and CVD modify the relationship between eGFR and specific histopathological features of nephrosclerosis.