Additional file 9 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells

Additional file 9 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells

Additional file 9: qRT-PCR (A, B), WB(C, D), and immunohistochemistry (E, F) showed that TGF-β1/FAP/VCAN axis regulates bladder cancer EMT in vivo. CAF has a stronger EMT-inducing effect than NF. Overexpression of FAP enhanced the EMT-inducing effects of stromal fibroblasts, while knockdown of FAP w...

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Hauptverfasser: Ping, Qinrong, Wang, Chunhui, Cheng, Xin, Zhong, Yiming, Yan, Ruping, Yang, Meng, Shi, Yunqiang, Li, Xiangmeng, Li, Xiao, Huang, Wenwen, Wang, Liqiong, Bi, Xiaofang, Hu, Libing, Yang, Yang, Wang, Yingbao, Gong, Rui, Tan, Jun, Li, Rui, Li, Hui, Li, Jian, Wang, Wenju, Li, Ruhong
Format: Dataset
Sprache:eng
Schlagworte:
Cancer
Cell Biology
FOS: Biological sciences
FOS: Clinical medicine
Genetics
Immunology
Medicine
Molecular Biology
Physiology
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Zusammenfassung:Additional file 9: qRT-PCR (A, B), WB(C, D), and immunohistochemistry (E, F) showed that TGF-β1/FAP/VCAN axis regulates bladder cancer EMT in vivo. CAF has a stronger EMT-inducing effect than NF. Overexpression of FAP enhanced the EMT-inducing effects of stromal fibroblasts, while knockdown of FAP weakened those effects.
DOI:10.6084/m9.figshare.23700672