Additional file 6 of Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2

Additional file 6: Fig. S6 Eriodictyol suppresses the activity of viral replication enzymes. A FRET-based enzymatic activity assay was performed to address the activity of RdRp A 3CLpro B and PLpro C under treatment with eriodictyol at the indicated concentrations. GS-443902, GC-376, and GRL-0617were used as the positive controls for the inhibitions of RdRp, 3CLpro, and PLpro activities, respectively. Data were shown as mean±SEM from three independent experiments with triplicates. ** p < 0.01 and *** p < 0.0001. D Schematics of the working model of eriodictyol in inhibiting viral replication by antagonizing RdRp activity. The working model was created by bioRENDER.