Additional file 7 of Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination

Additional file 7. AhR deficiency in microglia aggravates CNS inflammation. (A) KEGG pathway analysis of 214 upregulated genes unique to CX3CR1-AhR−/− mice after cuprizone administration. (B) GO term enrichment analysis of 214 upregulated genes unique to CX3CR1-AhR−/− mice after cuprizone administration. (C) Representative HE stained images in the corpus callosum of AhRfl/fl mice and CX3CR1-AhR−/− mice in the context of the end of week 6 in the cuprizone model. Scale bar: 50 μm. (D-G) mRNA expressions of Nos2, Il1b, Il6 and Ccl2 in the corpus callosum of AhRfl/fl mice and CX3CR1-AhR−/− mice at the end of week 6 of cuprizone model were evaluated by qRT-PCR (n = 4 mice per group). Data are shown as mean ± SEM and analyzed by two-way ANOVA with Tukey's multiple comparisons test. *p