Additional file 5 of Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancer

Additional file 4: Fig. S4. (A) Literature-supported ligand-receptor interactions in humans available at the CellChatDB database ( http://www.cellchat.org/ ) [35]. The 1,939 validated interactions included paracrine/autocrine signaling (61.8%), extracellular matrix (ECM) receptor interactions (21.7%) and cell-cell contact interactions (16.5%). (B) Circos plot showing the CellChatDB inferred cell-cell communication network based on single-cell RNA-Seq data across ovarian cancer cells (Ep1-5), myofibroblastic cancer-associated fibroblasts (myCAF1-2), inflammatory cancer-associated fibroblasts (iCAF1-2), macrophages (mac1-4), dendritic cells (DC1-2), B cells (B), T cells (T), and erythrocytes (ery) from ovarian cancer patients.