Immune persistence induced by two-dose BBIBP-CorV vaccine with different intervals, and immunogenicity and safety of a homologous booster dose in high-risk occupational population

The immune persistence of neutralizing antibodies elicited by BBIBP-CorV vaccines on day 0–14, 0–21 and 0–28 schedule, and the immunogenicity and safety of a homologous booster dose after different priming vaccination regimens is scarcely reported. : Responders (GMT≥16) at day 28, after priming with...

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Hauptverfasser: Yao, Tian, Zhang, Xiaohong, Mu, Shengcai, Guo, Yana, Xu, Xiuyang, Huo, Junfeng, Wei, Zhiyun, Liu, Ling, Li, Xiaoqing, Li, Hong, Xing, Rongqin, Feng, Yongliang, Chen, Jing, Feng, Lizhong, Wang, Suping
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Sprache:eng
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Zusammenfassung:The immune persistence of neutralizing antibodies elicited by BBIBP-CorV vaccines on day 0–14, 0–21 and 0–28 schedule, and the immunogenicity and safety of a homologous booster dose after different priming vaccination regimens is scarcely reported. : Responders (GMT≥16) at day 28, after priming with the two-dose vaccine, were followed up at 3, 6, and 10 months. Eligible participants received a homologous booster dose at month 10 and were followed-up 28 days post-booster. The GMT of neutralizing antibodies in 0–28d-10 m and 0–21d-10 m group were significantly higher than 0–14d-10 m group from month 3 (71.6 & 64.2 vs 46.4, p
DOI:10.6084/m9.figshare.21443269