"Mullberroside A" Could Serve as a Pan Inhibitor for the Tyrosine Kinase Domains of the HER Family

Illustration of the PCA plane; the upper left square indicates occupied (red) and unoccupied (black) HER1; the upper right square indicates occupied (blue) and unoccupied (green) HER2; the lower left square indicates occupied (brown) and unoccupied (yellow) HER3; and the lower right square indicates occupied (purple) and unoccupied (grey) HER4. Concerning HER4, the fifty frames of vector one for both the apo (blue) and holo (khaki) forms were matched to better visualize the major conformational difference between them. These changes appear to originate from the highly flactuated region 160-180 and the C-terminus.