Additional file 11 of Proteomic analysis of low- and high-grade human colon adenocarcinoma tissues and tissue-derived primary cell lines reveals unique biological functions of tumours and new protein biomarker candidates

Additional file 11. Analysis of proteins with significantly differential expression in HGCA cell lines compared to LGCA cell lines. A, Proteins with significantly increased abundance with a medium confidence level (0.4), with GO terms or KEGG or Reactome pathways of interest coloured as follows: Red – IFN-g-mediated signalling pathway; Blue – ferroptosis; Yellow – growth plate cartilage morphogenesis; Light Green – negative regulation of leukocyte mediated immunity; Pink – response to IFN-g; Teal – regulation of i-kappab kinase/nf-kappab signaling; Orange – cellular response to chemical stress; Dark Green – cytokine-mediated signaling pathway. B, Proteins with significantly decreased abundance with a medium confidence level (0.4), with GO terms or KEGG or Reactome pathways of interest coloured as follows: Red – MHC class I protein complex; Blue – filopodium membrane; Green – dystrophin-associated glycoprotein complex; Yellow – cell adhesion; Pink – cell junction; Orange – plasma membrane protein complex.