Additional file 7 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling

Additional file 7 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling

Additional file 7: Fig. S7. AEP promotes GBM progression by cleaving Tmod3 in vitro and in vivo. (A) CCK-8 assays of U87-MG and A172 cells with NC, AEP KD, AEP KD/tTmod3-N res, AEP KD/tTmod3-C res and AEP KD/tTmod3-N res/tTmod3-C res. (B) Representative images showing IHC staining of Tmod3, Ki-67 an...

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Hauptverfasser: Chen, Binghong, Wang, Mengying, Qiu, Junjun, Liao, Keman, Zhang, Wenrui, Lv, Qi, Ma, Chunhui, Qian, Zhongrun, Shi, Zhonggang, Liang, Rong, Lin, Yan, Ye, Jiazhou, Qiu, Yongming, Lin, Yingying
Format: Bild
Sprache:eng
Schlagworte:
Biochemistry
Biological Sciences not elsewhere classified
Biophysics
Cancer
Cell Biology
Developmental Biology
Hematology
Medicine
Molecular Biology
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Zusammenfassung:Additional file 7: Fig. S7. AEP promotes GBM progression by cleaving Tmod3 in vitro and in vivo. (A) CCK-8 assays of U87-MG and A172 cells with NC, AEP KD, AEP KD/tTmod3-N res, AEP KD/tTmod3-C res and AEP KD/tTmod3-N res/tTmod3-C res. (B) Representative images showing IHC staining of Tmod3, Ki-67 and Vinculin in the indicated transplantation tumors in nude mice. Scale bar, 80 μm.(C-D) Relative expression of Ki-67,Tmod3 and Vinculin in the indicated groups. Data are presented as the mean ±s.d. NC=negative control, cells expressing scramble shRNA. KD=knockdown, cells expressing AEP shRNA.*P
DOI:10.6084/m9.figshare.20175892