Additional file 1 of Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer

Additional file 1: Fig. S1. Single agent dose-response curves and IC50 determination. (A) Single agent cytotoxicity of compounds was evaluated in two BRCA1-deficient (KB1P-G3 and KB1P-B11) and two BRCA1-proficient (KP-3.33 and KP-6.3) mouse mammary tumor cell lines. Cells were permanently exposed to...

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Hauptverfasser:	Ratz, Leonie, Brambillasca, Chiara, Bartke, Leandra, Huetzen, Maxim A., Goergens, Jonas, Leidecker, Orsolya, Jachimowicz, Ron D., van de Ven, Marieke, Proost, Natalie, Siteur, Bjørn, de Korte-Grimmerink, Renske, Bouwman, Peter, Pulver, Emilia M., de Bruijn, Roebi, Isensee, Jörg, Hucho, Tim, Pandey, Gaurav, van Lohuizen, Maarten, Mallmann, Peter, Reinhardt, Hans Christian, Jonkers, Jos, Puppe, Julian
Format:	Bild
Sprache:	eng
Schlagworte:	Biochemistry Cancer Cell Biology FOS: Biological sciences Genetics Medicine Molecular Biology Pharmacology Plant Biology
Online-Zugang:	Volltext bestellen
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Zusammenfassung:	Additional file 1: Fig. S1. Single agent dose-response curves and IC50 determination. (A) Single agent cytotoxicity of compounds was evaluated in two BRCA1-deficient (KB1P-G3 and KB1P-B11) and two BRCA1-proficient (KP-3.33 and KP-6.3) mouse mammary tumor cell lines. Cells were permanently exposed to 10 different compound concentrations ranging from 20 nM to 20 µM for 72 hours. Cell viability was determined by measuring ATP content using CellTiter-Glo assay. The IC50 values were determined by logistic interpolation using GraphPad Prism software. Dotted lines represent IC50 concentration in the graph. See Additional file 8: Table S1 for IC50 values for the compounds and four different cell lines.
DOI:	10.6084/m9.figshare.20098267