Additional file 6 of Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

Additional file 6: Supplementary Figure 6. Analysis of microglia clustering in AppSAA mice. a-d Histological analysis of microglia and amyloid-β plaques in brain sections from 8-month-old AppSAA mice. Quantification of hippocampal areas covered by Iba1 (a), CD68 (b) and the percentage of the CD68 and Iba1 signals overlapping with amyloid-β plaques in the hippocampus (c) from AppSAA KI/KI mice. (d) Percentage of amyloid plaque overlapping with CD68 or Iba1 in the hippocampus or cortex. Graphs are box and whisker plots and P values: one-way ANOVA with Dunnett’s multiple comparison test, each group compared to the AppSAA +/+ control group (n=4-6 per group); *P < 0.05 and **P < 0.01.