Additional file 11 of Impact of APOE genotype on prion-type propagation of tauopathy

Additional file 11. Figure S11: Gliosis in PS19 mice heterozygous for APOE (B6N1 generation) injected with K18-tau aggregates in the hippocampus. K18-tau aggregates or PBS was injected into the left hippocampus of 2.5-month-old PS/E2h, PS/E3h and PS/E4h mice (B6N1 generation) and aged for 5 months. Representative images from the hippocampus (Hpc) and cortex (Ctx) of injected (ipsilateral, ‘IPSI’) and uninjected (contralateral, ‘CONTRA’) hemispheres showing pathology in PS/E2h, PS/E3h and PS/E4h mice. Microgliosis was assessed using Iba-1 antibody (a-d) and astrogliosis was assessed using GFAP antibody (e-h). Quantification of % immunoreactivity is presented from cortex (Ctx) or hippocampus (Hpc) of ipsilateral and contralateral hemispheres of K18-tau aggregate (c, d, g, h) or PBS injected (a, b, e, f) mice. n= 7-10 mice/genotype (K18-tau aggregate group); n= 6-8 mice/genotype (PBS group). 1-way ANOVA *p