Additional file 7 of Nos2−/− mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis

Additional file 7: Figure S6. CDC1551 i.c.vent.-infected Nos2−/− mice had larger granulomas with increased concentration of adhesion molecule ICAM-1 than CDC1551 i.v. mice. (a) CDC1551-infected mice by the two routes of infection demonstrate similar number of brain granulomas. (b) CDC1551 i.c.vent.-infected mice had larger granulomas than CDC1551 i.v.-infected mice. The number and size of granulomas in each group were respectively quantified from 6 different sections of 5–6 mice. CDC1551 i.c.vent.-infected mice show higher expression of (c) ICAM-1 compared to i.v.-infected mice, whereas (d) p-selectin expression was higher in i.v.-infected than i.c.vent.-infected mice. Bars represent median and IQR. Statistical analysis was conducted using Mann–Whitney test. **, p