MST1/2 in PDGFR-a+ cells negatively regulates TGF-β-induced Myofibroblasts Accumulation in Renal Fibrosis

MST1/2 in PDGFR-a+ cells negatively regulates TGF-β-induced Myofibroblasts Accumulation in Renal Fibrosis

Using a mouse model with Mst1/2 double knockout in PDGFRα+ cells, and a Mst1/2 inhibiter, we demonstrated that MST1/2, as a negative-feedback signal of TGF-β-induced fibroblast differentiation. Furthermore, we demonstrated that Hippo–MST as a negative feedback signal can decrease the renal fibrosis...

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Hauptverfasser: An, Yina, Ren, Yaqi, Wang, Jing, Zang, Jianghua, Gao, Ming, Wang, Haidong, Wang, Shuaiyu, Dong, Yanjun
Format: Bild
Sprache:eng
Schlagworte:
Cell Physiology
FOS: Basic medicine
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Zusammenfassung:Using a mouse model with Mst1/2 double knockout in PDGFRα+ cells, and a Mst1/2 inhibiter, we demonstrated that MST1/2, as a negative-feedback signal of TGF-β-induced fibroblast differentiation. Furthermore, we demonstrated that Hippo–MST as a negative feedback signal can decrease the renal fibrosis process. This finding contributes to understanding the mechanism of co-regulated renal remodeling post injury.
DOI:10.6084/m9.figshare.18864536