SUP FIGURE 3.pdf

Supplemental Figure 3: Comparison of gene expression for enzymes related to toxicant bioactivation pathways in air-liquid interface differentiated cells and airway-enriched source tissues from human, rhesus, and mouse. Transcript levels (normalized to RPL13A) were measured for microsomal epoxide hydrolase (mEH-A,B,C), cytochrome P450 (CYP) oxidoreductase (POR-D,E,F), and Heme Oxygenase 1 (HMOX1-G,H,I). Final sample sizes were between 3 and 6, except for the SmallAir groups with sample size of 2 presented on graphs without error bars and excluded from statistical assessment. No differences between the groups from the same species were statistically significant by 2-way ANOVA with Tukey’s Multiple Comparison post-hoc Test (alpha=0.05).