Additional file 1 of CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

Additional file 1: Fig. S1. Progressive development of amyloid pathology in 5xFAD mice. Representative images of the frontal cortex and hippocampus of F+/T− mice stained with W02 antibody showing the evolution of amyloid pathology in subiculum from 2.5 months to extension of amyloid pathology to the frontal cortex at 4 months and robust pathology at 7 months. Scale bar = 500 µm (FrCx = frontal cortex; HC = hippocampus). Quantitative analysis of W02 staining in frontal cortex and hippocampus of 2.5 months (n = 3), 4 months (n = 3) and 7 months (n = 3) old F+/T− mice. Data are presented as mean ± SEM; *p < 0.05; **p < 0.01; ***p < 0.001 one-way ANOVA with Tukey’s multiple comparison test