Additional file 4 of Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?

Additional file 4 : Figure S4. The influence of a hypoxic microenvironment on the glucose metabolism of SF. OASF and RASF were cultured for 4 days under hypoxic conditions (3% O2) either in the presence or absence of ThCM. a The amount of secreted [U-13C]-lactate and the ratio of [U-13C]-glucose metabolized by glycolysis (Gly) to that metabolized by oxidative phosphorylation (OXPHOS) was determined in SF culture supernatants using 1H NMR spectroscopy (n=12). b SF were stimulated by different dilutions of ThCM under hypoxia. [U-13C]-lactate concentrations were determined after 4 days of culture (n=6). Results are presented as the mean±SEM. (*) p