Supplementary Material for: Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

Supplementary Material for: Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedD...

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Hauptverfasser: Díaz-López, A., Becerra-Tomás, N., Ruiz, V., Toledo, E., Babio, N., Corella, D., Fitó, M., Romaguera, D., Vioque, J., Alonso-Gómez Á.M., Wärnberg, J., Martínez, J.A., Serra-Majem, L., Estruch, R., Tinahones, F.J., Lapetra, J., Pintó, X., Tur, J.A., López-Miranda, J., CanoIbañez, N., Delgado-Rodríguez, M., Matía-Martín, P., Daimiel, L., DePaz, J.A., Vidal, J., Vázquez, C., Ruiz-Canela, M., Bulló, M., Sorlí, J.V., Goday, A., Fiol, M., García-De-La-Hera, M., TojalSierra, L., Pérez-Farinós, N., Zulet M.Á., Sánchez-Villegas, A., Sacanella, E., Fernández-García, J.C., Santos-Lozano, J.M., Gimenez-Gracia, M., DelMarBibiloni, M., Diez-Espino, J., Ortega-Azorin, C., Castañer, O., Morey, M., Torres-Collado, L., SortoSanchez, C., Muñoz M.Á., Ros, E., Martinez-Gonzalez, M.A., Salas-Salvadó, J., Investigators, The PREDIMED-Plus
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Sprache:eng
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Medicine
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Zusammenfassung:Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled “PREvención con DIeta MEDiterránea-Plus” (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55–75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR (
DOI:10.6084/m9.figshare.13733335