Additional file 2 of Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin
Additional file 2: Fig. S3. Iron overload could cause bone marrow damage in vivo. A—The cell viability of mononuclear cells in the bone marrow of the iron-overloaded mice decreased. B and C—LIP (B) and mROS (C) levels increased in iron-overloaded mice. D and E—SOD2 (D) and SIRT3 (E) activities decre...
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| creator | Zhou, Shujuan Sun, Lan Shanhu Qian Yongyong Ma Ruye Ma Yuqing Dong Yifen Shi Songfu Jiang Haige Ye Zhijian Shen Shenghui Zhang Jianping Shen Yu, Kang Siqian Wang |
| description | Additional file 2: Fig. S3. Iron overload could cause bone marrow damage in vivo. A—The cell viability of mononuclear cells in the bone marrow of the iron-overloaded mice decreased. B and C—LIP (B) and mROS (C) levels increased in iron-overloaded mice. D and E—SOD2 (D) and SIRT3 (E) activities decreased in iron-overloaded mice. F—Iron-overloaded mice showed decreased Hb levels, PLT counts, and WBC counts in their peripheral blood. The values are presented as the means ± SEM, **p |
| doi_str_mv | 10.6084/m9.figshare.13566156 |
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Iron overload could cause bone marrow damage in vivo. A—The cell viability of mononuclear cells in the bone marrow of the iron-overloaded mice decreased. B and C—LIP (B) and mROS (C) levels increased in iron-overloaded mice. D and E—SOD2 (D) and SIRT3 (E) activities decreased in iron-overloaded mice. F—Iron-overloaded mice showed decreased Hb levels, PLT counts, and WBC counts in their peripheral blood. 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Iron overload could cause bone marrow damage in vivo. A—The cell viability of mononuclear cells in the bone marrow of the iron-overloaded mice decreased. B and C—LIP (B) and mROS (C) levels increased in iron-overloaded mice. D and E—SOD2 (D) and SIRT3 (E) activities decreased in iron-overloaded mice. F—Iron-overloaded mice showed decreased Hb levels, PLT counts, and WBC counts in their peripheral blood. 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Iron overload could cause bone marrow damage in vivo. A—The cell viability of mononuclear cells in the bone marrow of the iron-overloaded mice decreased. B and C—LIP (B) and mROS (C) levels increased in iron-overloaded mice. D and E—SOD2 (D) and SIRT3 (E) activities decreased in iron-overloaded mice. F—Iron-overloaded mice showed decreased Hb levels, PLT counts, and WBC counts in their peripheral blood. The values are presented as the means ± SEM, **p</abstract><pub>figshare</pub><doi>10.6084/m9.figshare.13566156</doi><orcidid>https://orcid.org/0000-0003-3809-7613</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biochemistry Biological Sciences not elsewhere classified Cancer Cell Biology FOS: Biological sciences FOS: Clinical medicine FOS: Health sciences FOS: Mathematics Genetics Hematology Immunology Infectious Diseases Mathematical Sciences not elsewhere classified Molecular Biology Physiology |
| title | Additional file 2 of Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin |
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